張吉鳳

人體解剖學系 副教授

個人簡介


職稱:副教授

學科專業:人體解剖學

研究方向:認知、情緒及發育障礙的神經環路和突觸可塑性機制

行政職務:人體解剖學實驗教學中心主任

電子郵箱:tzjf_jennifer@jnu.edu.cn

個人介紹:張吉鳳,女,太阳集团app首页基礎醫學院人體解剖學系副教授,醫學博士,碩士研究生導師。從事人體解剖學、系統解剖學、局部解剖學的教學工作及神經解剖的科研工作,研究方向為認知與發育障礙神經系統疾病的環路和突觸可塑性機制。教學方面主持太阳集团app首页教學改革項目7項,發表教學改革類文章15篇,主編教材2部,副主編教材1部,獲得國家級優秀論文一等獎,獲得第十屆太阳集团app首页教育教學成果獎“特等獎”(第二完成人),指導本科生獲得廣東省大學生創新創業項目1項,太阳集团app首页創新創業項目3項和挑戰杯項目1項。科研方面主要利用分子生物學、生物化學、分子影像學、光遺傳學、電生理學及行為學等技術手段研究情緒和認知相關的神經系統疾病的環路和突觸可塑性機制。主持國家自然科學基金青年項目1項,廣東省自然科學基金2項、中國博士後科學基金2項,以第一和通訊作者(共同通訊)在Neuropsychopharmacology、Translational Psychiatry、Neurobiology of Disease、Molecular Neurobiology等國際期刊發表SCI論文25篇。


學習工作經曆


2016年11月-至今,太阳集团app首页基礎醫學院解剖學系,講師,副教授;

2014年10月-2016年10月,太阳集团app首页基礎醫學院,博士後研究;

2012年9月-2014年9月,中山大學中山醫學院,博士後研究;

2002年7月-2006年9月,華北理工大學,助教,講師;

2009年9月-2012年7月,中山大學中山醫學院分子醫學專業,獲醫學博士學位;

2006年9月-2009年7月,太阳集团app首页醫學院人體解剖學專業,獲醫學碩士學位;

1997年9月-2002年7月,華北理工大學臨床醫學專業,獲醫學學士學位。


主要論文


[1] Li F#, Zheng X#, Wang H, Meng L, Chen M, Hui Y, Liu D, Xie K, Zhang J*, Guo G*. Mediodorsal thalamus projection to medial prefrontal cortical mediates social defeat stress-induced depression-like behaviors. Neuropsychopharmacology. 2024. https://doi.org/10.1038/s41386-024-01829-y. 

[2] Zhang W#, Zhang J#, Zhang Z#, Cha S, Li J, Chen L, Wu J, Teng J, Guo G*, Zhang J*. Effects of deSUMOylated spastin on AMPA receptor surface delivery and synaptic function are enhanced by phosphorylating at Ser210. Mol Neurobiol. 2024. doi: 10.1007/s12035-024-03935-w. 

[3] Song X#, Zhang J#, Shen S#, Liu D, Zhang J, Yin W, Ye G, Wang L, Cai L, Hou H*, Qiu X*. Cardiac-adaptive conductive hydrogel patch enabling construction of mechanical-electrical anisotropic microenvironment for heart repair. Research(Wash D C). 2023, 6: 0161.

[4] Zhang H#, Yu G#, Li J#, Tu C, Hui Y, Liu D, Chen M, Zhang J*, Gong X*, Guo G*. Overexpressing lnc240 rescues learning and memory dysfunction in hepatic encephalopathy through miR-1264-5p/MEF2C axis. Mol Neurobiol. 2023, 60(4): 2277-2294.

[5] Chen M#, Jiang Y#, Li X#, Li J, Tu C, Zhang H, Gong X, Yu G*, Guo G*, Zhang J*. Enriched environment ameliorates learning and memory deficits in hepatic encephalopathy mice by restoration of the structure of dendrites and dendritic spines. Brain Res. 2023, 1804: 148264. 

[6] Wang H#, Li F#, Zheng X#, Meng L, Chen M, Hui Y, Li Y, Xie K, Zhang J*, Guo G*. Social defeat drives hyperexcitation of the piriform cortex to induce learning and memory impairment but not mood-related disorders in mice. Transl Psychiatry. 2022, 12(1):380. 

[7] Zhu W#, Wu F#, Li J, Meng L, Zhang W, Zhang H, Cha S, Zhang J*, Guo G*. Impaired learning and memory generated by hyperthyroidism is rescued by restoration of AMPA and NMDA receptors function. Neurobiol Dis. 2022, 171:105807. 

[8] Zhang J#, Zilundu PLM#, Fu R, Zheng X, Zhou L*, Guo G*. Medical students' perceptions and performance in an online regional anatomy course during the Covid-19 pandemic. Anat Sci Educ. 2022, 15(5):928-942. 

[9] Zhang J#,, Zilundu PLM#,, Zhang W#,, Yu G, Li S, Zhou L*, Guo G*. The use of a surgical boot camp combining anatomical education and surgical simulation for internship preparedness among senior medical students. BMC Med Educ. 2022, 22(1): 459. 

[10] Zhu W#, Wu F#, Hu J, Wang W, Zhang J*, Guo G*. Structural investigation of the interaction mechanism between chlorogenic acid and AMPA receptor via in silico approaches. Molecules. 2022, 27(11): 3394. 

[11] Zhang H#, Zhang W#, Yu G#, Li F, Hui Y, Cha S, Chen M, Zhu W, Zhang J*, Guo G*, Gong X*. Comprehensive analysis of lncRNAs, miRNAs and mRNAs in mouse hippocampus with hepatic encephalopathy. Front Genet. 2022, 13:868716. 

[12] Hui Y#, Zheng X#, Zhang H#, Li F, Yu G, Li J, Zhang J*, Gong X*, Guo G*. Strategies for targeting neural circuits: how to manipulate neurons using virus vehicles. Front Neural Circuits. 2022,16: 882366. 

[13] Cheng L#, Chen K#, Li J#, Wu J, Zhang J, Chen L, Guo G*, Zhang J*. Phosphorylation of CRMP2 by Cdk5 negatively regulates the surface delivery and synaptic function of AMPA receptors. Mol Neurobiol. 2022, 59(2): 762-777. 

[14] Chen L#, Wang H#, Cha S#, Li J, Zhang J, Wu J, Guo G*, Zhang J*. Phosphorylation of spastin promotes the surface delivery and synaptic function of AMPA receptors. Front Cell Neurosci. 2022, 16:809934. 

[15] Li S#, Zhang J#, Zhang J#, Li J, Cheng L, Chen L, Cha C*, Guo G*. Spastin interacts with CRMP2 to regulate neurite outgrowth by controlling microtubule dynamics through phosphorylation modifications. CNS Neurol Disord Drug Targets, 2021, 20(3):249-265. 

[16] Zhang J#, Zilundu PLM, Zhou L, Guo G*. Supplementary regional anatomy teaching by surgeons enhances medical students mastery of anatomical knowledge and positively impacts their choice of future career. J Surg Educ. 2020, 77(5):1113-1120. 

[17] Zhang J#, Li J#, Yin Y#, Li X, Jiang Y, Wang Y, Cha C*, Guo G*. Collapsin response mediator protein 2 and endophilin2 coordinate regulation of AMPA receptor GluA1 subunit recycling. Front Mol Neurosci, 2020, 13: 128. 

[18] Li J#, Wu F#, Cheng L, Zhang J, Cha C, Chen L, Feng T, Zhang J*, Guo G*. A nuclear localization signal is required for the nuclear translocation of Fign and its microtubule severing function. Mol Med Rep. 2020, 21(6): 2367-2374. 

[19] Zhang Z#, Zhang J#, Li J, Zhang J, Chen L, Li Y*, Guo G*. Ketamine regulates phosphorylation of CRMP2 to mediate dendritic spine plasticity. J Mol Neurosci, 2020, 70(3): 353-364. 

[20] Yin Y#, Cha C#, Wu F, Li J, Li S, Zhu X, Zhang J*, Guo G*. Endophilin 1 knockdown prevents synaptic dysfunction induced by oligomeric amyloid β. Mol Med Rep, 2019, 19(6): 4897-4905. 

[21] Zhang J#, Zhao B#, Zhu X#, Li J, Wu F, Li S, Gong X, Cha C*, Guo G*. Phosphorylation and SUMOylation of CRMP2 regulate the formation and maturation of dendritic spines. Brain Res Bull. 2018, 139: 21-30. 

[22] Zhang J#, Yin Y#, Ji Z, Cai Z, Zhao B, Li J, Tan M*, Guo G*. Endophilin2 interacts with GluA1 to mediate AMPA receptor endocytosis induced by oligomeric amyloid-β. Neural Plast, 2017, 2017:8197085. 

[23] Cha C#, Zhang J#, Ji Z, Tan M, Li S, Wu F, Chen K, Gong S, Guo G*, Lin H*. CRMP4 regulates dendritic growth and maturation via the interaction with actin cytoskeleton in cultured hippocampal neurons. Brain Res Bull, 2016, 124: 286-94. 

[24] Zhang J#, Tan M#, Yin Y, Ren B, Jiang N, Guo G*, Chen Y*. Distinct functions of endophilin isoforms in synaptic vesicle endocytosis. Neural Plast. 2015, 371496. 

[25] Zhang J, Fan J, Tian Q, Song Z, Zhang J F, Chen Y*. 2012. Characterization of two distinct modes of endophilin in clathrin-mediated endocytosis[J]. Cell Signal, 24(11): 2043-2050.


學術著作 


1.《系統解剖生理學》.  華中科技大學出版社,2023年.(主編)

2. 《人體解剖生理學》. 北京大學醫學出版社,2020年(主編)

3. 《系統解剖學》.北京大學醫學出版社,2018年(副主編)

4. 《Grant解剖學操作指南》(第17版). 北京科學技術出版社,2022年 (參譯)


獲獎及榮譽


1. 2020 年第十屆太阳集团app首页教育教學成果獎“特等獎”(第二完成人)

2. 2019年9月榮獲基礎醫學院2019年新任教師教學設計競賽二等獎

3. 2019年8月,外科醫生走進局部解剖學課堂有助于知識掌握和未來職業規劃, 獲得全國高等院校第五屆實驗教學及實驗技術工作者優秀論文一等獎(第一作者)

4. 2018年5月榮獲太阳集团app首页基礎醫學院2018年“德仁杯”教學競賽二等獎

5. 2016年12月榮獲太阳集团app首页第四屆本科課程新任教師教學競賽自然科學組二等獎


學術兼職


廣東省解剖學會第十四屆理事會 理事

中國研究型醫院學會神經再生與修複專業委員會 青年委員

中國研究型醫院學會神經再生與修複專業委員會周圍神經損傷與修複學組 委員

中國解剖學會第十七屆理事會虛拟現實分會 委員