個人簡介

職稱：副研究員

學科專業：公共衛生與預防醫學

研究方向：藥代動力學及藥物新劑型

電子郵箱：orangefume@hotmail.com

個人簡介：

董棟，女，太阳集团app首页基礎醫學院副研究員，博士畢業于University of Houston。一直從事藥物代謝及藥物新劑型的研究，主要研究内容為藥物II相代謝——外排轉運相互作用機制和微納米制劑制備、體外表征及其體内藥物動力學

。主持國家自然科學基金1項，廣東省自然科學基金1項，廣東省醫學科研基金1項，獲廣州市人才專項1項，發表SCI論文30餘篇，申請發明專利9項。

學習科研經曆

2015.09-至今，太阳集团app首页，基礎醫學院，副研究員

2013.08-2015.08，太阳集团app首页， 生物醫學工程轉業，博士後 

2009.08-2012.12，美國休斯敦大學，藥劑學專業，博士

2005.09-2008.07，複旦大學，生藥學專業，碩士

2001.09-2005.07，蘇州大學，藥學專業，學士

主要論文

第一（含共一）或通訊作者發表A1類SCI論文：

1. Dong D, Wu B, Chow D, Hu M. Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures and in silico modeling. Drug Metab Rev. 2012;44(2):192-208. 

2. Zhang X, Dong D#, Wang H, Ma Z, Wang Y, Wu B. Stable Knock-down of Efflux Transporters Leads to Reduced Glucuronidation in UGT1A1-Overexpressing HeLa Cells: The Evidence for Glucuronidation-Transport Interplay. Mol Pharm. 2015;12(4):1268-78.

3. Dong D, Wang X, Wang H, Zhang X, Wang Y, Wu B. Elucidating the in vivo fate of nanocrystals using a physiologically based pharmacokinetic model: a case study with the anticancer agent SNX-2112. Int J Nanomedicine. 2015;10:2521-35. 

4. Dong D, Peng X, Liu J, Qian H, Li J, Wu B. Morbid Obesity Alters Both Pharmacokinetics and Pharmacodynamics of Propofol: Dosing Recommendation for Anesthesia Induction. Drug Metab Dispos. 2016;44(10):1579-83.

5. Zhang T, Dong D#, Lu D, Wang S, Wu B. Cremophor EL-based nanoemulsion enhances transcellular permeation of emodin through glucuronidation reduction in UGT1A1-overexpressing MDCKII cells. Int J Pharm. 2016;501(1-2):190-8.

6. Dong D, Quan E, Yuan X, Xie Q, Li Z, Wu B. Sodium Oleate-Based Nanoemulsion Enhances Oral Absorption of Chrysin through Inhibition of UGT-Mediated Metabolism. Mol Pharm. 2017;14(9):2864-2874. 

7. Yuan X, Xie Q, Su K, Li Z, Dong D*, Wu B. Systemic delivery of the anticancer agent arenobufagin using polymeric nanomicelles. Int J Nanomedicine. 2017;12:4981-4989. 

8. Lu D, Dong D#, Xie Q, Li Z, Wu B. Disposition of Mianserin and Cyclizine in UGT2B10-Overexpressing Human Embryonic Kidney 293 Cells: Identification of UGT2B10 as a Novel N-Glucosidation Enzyme and Breast Cancer Resistance Protein as an N-Glucoside Transporter. Drug Metab Dispos. 2018;46(7):970-979. 

9. Xue Yuan, Dong D#, Zhijie Li, Baojian Wu. Rev-erba activation down-regulates hepatic Pck1 enzyme to lower plasma glucose in mice. Pharmacol Res. 2019;141:310-318.

獲獎及榮譽

廣州市珠江科技新星，2016年

學術兼職

1、美國藥學科學家協會（AAPS）會員

2、藥物緩控釋協會（CRS）會員，

3、Xenobiotica、International Journal of Nanomedicine、Journal of Chromatography B、Journal of Pharmaceutical and Biomedical Analysis等SCI雜志審稿人。