肖飛

藥理學系 副教授

個人簡介


  

職稱:副教授

行政職務:藥理系主任  

學科專業:藥理學

研究方向:

神經藥理學

電子郵箱:xiaofei@jnu.edu.cn

個人簡介:

肖飛,醫學博士,副教授,碩士生導師,太阳集团app首页醫學院藥理學系主任。從事藥理學研究,研究方向為神經退行疾病發病機制與促神經再生藥物研究。指導本科生創新訓練項目5項,主持國家自然基金課題1項,廣東省自然基金課題2項,廣東省醫學科學技術研究基金1項,廣州市科技計劃項目1項。參與阿爾茨海默病相關課題7項。已發表相關論文32篇,SCI收錄24篇(一作或通迅作者15篇)。申請專利4項,其中授權3項。獲廣東省科學技術獎三等獎1項,畢業博士論文被太阳集团app首页授予優秀博士研究生論文。目前任廣東省藥理學會理事,廣東省藥理學會神經藥理學專業委員會委員,廣東省藥理學會藥物毒理專業委員會委員,廣東省神經科學學會理事。廣東省自然基金評審專家,《中華神經醫學》雜志審稿專家。


學習經


1995.09-2000.07,武漢大學/醫學院臨床醫學專業,獲醫學學士學位;      
2000.09-2003.07,太阳集团app首页/藥學院藥理學專業,獲醫學碩士學位;                
2007.09-2010.07,太阳集团app首页/醫學院病理學與病理生理學專業,獲醫學博士學位;


工作經


2003.07-2005.10,太阳集团app首页藥學院神經藥理研究室, 研究實習員;
2005.11-2012.10,太阳集团app首页醫學院病理生理教研室, 助理研究員;
2012.10-至今,太阳集团app首页醫學院藥理學系主任,機能中心主任,碩士生導師,副教授。


主要論文


1) Zhang Z, Wang Z, Ling Z, Li Y, Pan J, Gao Q, Zhang J, Yan L, Zhang Z, Li J, Xiao F(通訊作者). A screened PirB antagonist peptide antagonizes Abeta42-mediated inhibition of neurite outgrowth in vitro. Appl Microbiol Biotechnol. 2021 Jun 1. doi: 10.1007/s00253-021-11363-2.
2) Xie QQ, Feng X, Huang Y, Fang N, Yi H, Wang ZJ, Cao Q, Lou GF, Pan JP, Hu Y, Li, F. C,Zheng, Q,Xiao F(通訊作者). Nogo66 promotes beta-amyloid protein secretion via NgR/ROCKdependent BACE1 activation. Mol Med Rep. 2021;23(3).
3) Huang YY, Fang N, Luo HR, Gao F, Zou Y, Zhou LL, Zeng QP, Fang SS, Xiao F(通訊作者), Zheng Q: RP1, a RAGE antagonist peptide, can improve memory impairment and reduce Abeta plaque load in the APP/PS1 mouse model of Alzheimer's disease. Neuropharmacology 2020, 180:108304.
4) Wang JH, Chen KQ, Jiang JX, Li HY, Pan JP, Su JY, Wang L, Hu Y, Mi XN, Xin YR, Xiao F(通訊作者), Luo HM: Excretion, Metabolism and Cytochrome P450 Inhibition of Methyl 3,4-Dihydroxybenzoate (MDHB): A Potential Candidate to Treat Neurodegenerative Diseases. Eur J Drug Metab Ph 2020, 45(1):51-69.
5) Xin YR, Jiang JX, Hu Y, Pan JP, Mi XN, Gao Q, Xiao F(通訊作者), Zhang W, Luo HM: The Immune System Drives Synapse Loss During Lipopolysaccharide-Induced Learning and Memory Impairment in Mice. Front Aging Neurosci 2019, 11:279.
6) Pan JP, Hu Y, Wang JH, Xin YR, Jiang JX, Chen KQ, Yang CY, Gao Q, Xiao F(通訊作者), Yan L et al: Methyl 3,4-Dihydroxybenzoate Induces Neural Stem Cells to Differentiate Into Cholinergic Neurons in vitro. Front Cell Neurosci 2018, 12:478.
7) Rendong Hu,Qiaoyu Cao ,Zhongqing Sun, Jinying Chen , Xiao F(通訊作者), Qing Zheng:A novel method of neural differentiation of PC12 cells by using Opti-MEM as a basic induction medium,International Journal of Molecular Medicine. 2018 Jan;41(1):195-201.
8) Yu Li , Zhongqing Sun, Qiaoyu Cao, Meiwan Chen, Huanmin Luo, Xi Lin, Xiao F(通訊作者):A role of amyloid β-protein receptors in mediating synaptic plasticity, Biomedical Reports. 2017 Apr;6(4):379-386.
9) Huimin Li, Yinglu Shi, Di Wen, Huanmin Luo, Xi Lin, Xiao F(通訊作者): A novel effective chemical Hemin for the treatment of acute carbon monoxide poisoning in mice. Experimental and Therapeutic Medicine. 2017 Nov;14(5):5186-5192..
10) Cai Y, Sun Z, Fang X, Fang X, Xiao F(通訊作者), Wang Y, Chen M: Synthesis, characterization and anti-cancer activity of Pluronic F68-curcumin conjugate micelles. Drug delivery 2015:1-9.
11) Dai XY, Sun ZQ, Liang R, Li Y, Luo HM, Huang YD, Chen MW, Su ZJ, Xiao F(通訊作者): Recombinant Nogo-66 via soluble expression with SUMO fusion in Escherichia coli inhibits neurite outgrowth in vitro. Appl Microbiol Biot 2015, 99(14):5997-6007.
12) Sun ZQ, Dai XY, Li Y, Jiang SW, Lou GF, Cao QY, Hu RD, Huang YD, Su ZJ, Chen MW, Sun J, Xiao F(通訊作者): A novel Nogo-66 receptor antagonist peptide promotes neurite regeneration in vitro. Mol Cell Neurosci 2016, 71:80-91.
13) Xiao F(第一作者), Li XG, Zhang XY, Hou JD, Lin LF, Gao Q, Luo HM: Combined administration of D-galactose and aluminium induces Alzheimer-like lesions in brain. Neurosci Bull 2011, 27(3):143-155.
14) Xiao F(第一作者), Lin LF, Cheng X, Gao Q, Luo HM: Nogo-66 receptor activation inhibits neurite outgrowth and increases beta-amyloid protein secretion of cortical neurons. Mol Med Rep 2012, 5(3):619-624.
15) Xu YQ, Sun ZQ, Wang YT, Xiao F(通訊作者), Chen MW: Function of Nogo-A/Nogo-A Receptor in Alzheimer's Disease. Cns Neurosci Ther 2015, 21(6):479-485.


學術著作


1. 盛樹力主編《老年性癡呆及相關疾病》,科技文獻出版社,2006年4月出版。(參與編寫第十五章老年性癡呆的動物模型及評價)
2. 羅煥敏主編《神經藥理學基礎》,太阳集团app首页出版社,2011年6月出版。(參與編寫第十二章 抗腦衰老及抗老年癡呆藥物)


獲獎及榮譽


1. 2007年榮獲廣東省科學技術獎三等獎。(羅煥敏,肖飛,李曉光. 抗老年癡呆藥物篩選系統的建立和應用. No. B17-0-3-01)


學術兼職


1. 中華神經醫學審稿專家;
2. 廣東省藥理學會理事;
3. 廣東省藥理學會神經藥理學專業委員會委員;                    

4. 廣東省藥理學會藥物毒理專業委員會委員;                                             

5. 廣東省神經科學學會理事.