生物化學與分子生物學 副教授
職稱:副教授
學科專業:生物化學與分子生物學
研究方向:醫學分子生物學與幹細胞轉化醫學
個人簡介:科研方向專注于幹細胞生物學研究,2011-2012年在美國康乃涅克大學遺傳發育學實驗室做訪問學者,主要從事分子生物學技術調控幹細胞定向誘導分化的研究。近年來結合臨床運動系統的醫學難題,專注幹細胞臨床轉化機制的研究,尤其是椎間盤髓核幹細胞的生物學特性及增殖、分化的分子機理。
2003/09 – 2006/06, 中山大學,幹細胞與組織工程研究中心,博士
1999/09 – 2002/06,皖南醫學院,基礎醫學院病理生理學系,碩士
1991/09 – 1996/06,皖南醫學院,臨床醫學系,學士
2011/04- 2012/05 美國Connecticut 州立大學,醫學中心遺傳發育學系,訪問學者&博士後
2008/10 - 至今, 太阳集团app首页醫學院 生物化學系, 副教授
2006/09 -2008/09 太阳集团app首页醫學院 生物化學系, 講師
1.Hao Wu, Xiaoli Zeng, Yupan Shang,Lek Hang Cheang, Jiaqing Zhang.Effect of Conditioned Medium from Human Umbilical Cord-Derived Mesenchymal Stromal Cells on Rejuvenation of Nucleus Pulposus Derived stem/Progenitor Cells from Degenerated Intervertebral Disc. International Journal of Stem Cells 2020. https://doi.org/10.15283/ijsc20027 (通訊作者)
2.Hao Wu, Xiaoli Zeng, Yupan Shang,Lek Hang Cheang, Jiaqing zhang.Regenerative potential of human nucleus pulposus resident stem/progenitor cells declines with ageing and intervertebral disc degeneration. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2018. DOI: 10.3892/ijmm.2018.3766 (通訊作者)
3.Hao Wu, Xiaoli Zeng, Yupan Shang,Lek Hang Cheang, Jiaqing Zhang. Comparison of nucleus pulposus stem/progenitor cells isolated from degenerated intervertebral discs with umbilical cord derived mesenchymal stem cells. Experimental Cell Research 2017(361):324-332(A1, II區,IF 3.6)(通訊作者)
4.Hao Wu, Yupan Shang, Jiaqing Zhang, Lek Hang Cheang,Xiaoli Zeng and Mei Tu The effects of liquid crystal-based composite substrates on cell functional responses of human umbilical cord-derived mesenchymal stem cells by mechano-regulatory process Journal of Biomaterials Applications 2017, Vol. 32(4) 492–503 (A1, II區,IF 3.2)(通訊作者)
5.尚玉攀, 吳 昊, 曾曉麗, 鄭力恒, 餘 俊, 肖黔龍, 屠 美, 張嘉晴, 從脊柱内鏡手術摘除組織中分離髓核間充質幹細胞及其生物學特征鑒定中國病理生理雜志 2017, 33 (6): (通訊作者)
6.Zhang JQ, Yu WH, Zhang XM, Peng YW, Li WH, Chen R, Yu XB, Li SH, Xiang P. Establishment and characteristics of hybrid embryonic stem cell lines from blastocysts of the(C57BL/6J× 129/J)F1 mouse(英文). 中國病理生理雜志 Chinese Journal of pathophysiology 2006, 22(1):7-11(第一作者)
7.Li Kairong, Zhang Jiaqing, Li James YH. Gbx2 plays an essential but transient role in the formation of thalamic nuclei. PLoS One. 7(10) 2012;
8.Yang Chen, Lei Wang, Hao Huang, Ruizhe Tan, Jupeng Zhao, Shenyu Yang, Rong Zeng, Hao Wu,Jiaqing Zhang, Bin Yu, Mei Tu. Mechano-regulatory Cellular Behaviors of NIH/3T3 in Response to the Storage modulus of Liquid Crystalline Substrates. Journal of the Mechanical Behavior of Biomedical Materials , 2016.4, 57: 42~54
9.Tan Wen-cheng, Zha Zhen-gang*.,Zhang Jia-qing,Zheng Li-heng,Liang Yao-zhong,Xia Ji-sheng,Huang Xin-pei1,Wu Hao,Lin Hong-sheng Animal-origin osteochondral scaffold combined with bone marrow mesenchymal stem cells/chondrocytes for repair of composite osteochondral defects in rabbit knee joints Journal of Clinical Rehabilitative Tissue Engineering Research, 89(12):209-214. 2011
10.Zhang HT, Zha ZG*, Cao JH, Liang ZJ, Wu H, He MT, Yao P, Zhang JQ. Apigenin accelerates lipopolysaccharide induced apoptosis in mesenchymal stem cells through suppressing vitamin D receptor expression. Chin Med J (Engl).124(21):3537-45. 2011
11.郭燕珊; 吳昊; 鄭力恒; 尚玉攀; 屠美; 張嘉晴(通訊作者)聚合物/液晶細胞模型的構建及其表面彈性對大鼠骨髓幹細胞黏附的影響,中國病理生理雜志 2015,31 (6):1064-1069.
12.李佳成; 郭燕珊; 屠美; 吳昊; 鄭力恒; 張嘉晴(通訊作者);胚胎幹細胞條件培養基對人脂肪幹細胞增殖及分化能力的影響 中山大學學報(醫學科學版)2014, 35 (2):169-176.
13.Zhang JQ, Yu XB, Ma BF, Yu WH, Zhang AX, Huang G, Mao FF, Zhang XM, Wang ZC,Li SN, Lahn BT, Xiang AP*. Neural differentiation of embryonic stem cells induced by conditioned medium from neural stem cell. Neuroreport. 17;17(10):981-6. 2006
14.Zhang AX, Yu WH, Ma BF, Yu XB, Mao FF, Liu W, Zhang JQ, Zhang XM, Li SN, Li MT, Lahn BT, Xiang AP*. Proteomic identification of differently expressed proteins responsible for osteoblast differentiation from human mesenchymal stem cells. Mol Cell Biochem. 304(1-2):167-79. 2007
15.Ma BF, Liu XM, Xie XM, Zhang AX, Zhang JQ, Yu WH, Zhang XM, Li SN, Lahn BT, Xiang AP*.. Slower cycling of nestin-positive cells in neurosphere culture. Neuroreport. 17(4):377-81. 2006.
2015年 獲太阳集团app首页本科課程全英語教學競賽校長獎二等獎
2015年 獲太阳集团app首页醫學院本科課程全英語教學競賽一等獎
2008年獲太阳集团app首页醫學院本科教學競賽三等獎
中國生物化學與分子生物學學會會員