病理學與病理生理學 副教授
職稱：副教授
學科專業：病理學與病理生理學
研究方向：炎症和腫瘤轉移、耐藥、外泌體液态活檢和個體化腫瘤治療
電子郵箱：luellawang@ 163.com
個人簡介：
太阳集团app首页基礎醫學院副教授，太阳集团app首页附屬第一醫院博士後。研究方向：我國高發惡性腫瘤的診治的轉化研究和應用，包括外泌體液體活檢和免疫治療。在研究領域一流期刊發表多篇學術論文，以第一作者發表SCI收錄文章8篇，包括TOP期刊PNAS、Oncogene、Cancer Letters等，其中單篇最高他引次數将近60次。主持國家自然科學基金1項、省部級課題1項、中國博士後基金1項，參與了多項國家自然科學基金。2020年獲得廣東省科技進步獎二等獎1項。
2015/09-2019/07，汕頭大學，病理學與病理生理學，博士
2013/07-2015/08，汕頭大學，病理學與病理生理學，碩士
2008/09-2013/06, 南華大學，預防醫學，學士
2019/07-2021/12，太阳集团app首页，第一附屬醫院，博士後;
2022/01-至今，太阳集团app首页，太阳集团1088vip
1.Wang L#, Liang D, Xiong X, Lin Y, Zhu J, Yao Z, Wang S, Guo Y, Chen Y,Geary K, Pan Y, Zhou F, Gao S, Zhang D, Yeung SJ, Zhang H*. Repurposing dextromethorphan and metformin for treating nicotine-induced cancer by directly targeting CHRNA7 to inhibit JAK2/STAT3/SOX2 signaling. Oncogene 2021 Mar;40(11) .
2.Lu Wang#, Xiao Xiong, Zhimeng Yao, Jianlin Zhu, Yusheng Lin, Wan Lin, Kai Li, Xiaozheng Xu, Yi Guo, Yuping Chen, Yunlong Pan, Fuyou Zhou, Jun Fan, Yan Chen, Shegan Gao*, Sai-Ching Jim Yeung and Hao Zhang*. Chimeric RNA ASTN2-PAPPAas aggravates tumor progression and metastasis in human esophageal cancer. Cancer Lett, 2021 Mar 31;501:1-11.
3.Wang L#, Li K#, Lin X#, Yao Z, Wang S, Xiong X, Ning Z, Wang J, Xu X, Jiang Y, Liu D, Chen Y, Zhang D, Zhang H*: Metformin induces human esophageal carcinoma cell pyroptosis by targeting the miR-497/PELP1 axis. Cancer Lett, 2019, 450: 22-31
4.Xiong X#, Ke X#, Wang L#, Yao Z, Guo Y, Zhang X, Chen Y, Pang CP, Schally AV*, Zhang H*: Splice variant of growth hormone-releasing hormone receptor drives esophageal squamous cell carcinoma conferring a therapeutic target. Proc Natl Acad Sci USA, 2020, 117(12): 6726-6732
5.Du L#, Wang L#, Gan J#, Yao Z, Lin W, Li J, Guo Y, Chen Y, Zhou F*, Jim Yeung SC, Coppes RP, Zhang D, Zhang H*: MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis. iScience, 2019, 22: 353-368
6.Wang L#, Li W#, Li K#, Guo Y, Liu D, Yao Z, Lin X, Li S, Jiang Z, Liu Q, Jiang Y, Zhang B, Chen L, Zhou F, Ren H, Lin D, Zhang D, Yeung SJ, Zhang H*: The oncogenic roles of nuclear receptor coactivator 1 in human esophageal carcinoma. Cancer Med, 2018, 7(10): 5205-5216
7.Zheng L#, Wang L#, Gan J, Zhang H*: RNA activation: promise as a new weapon against cancer. Cancer Lett, 2014, 355(1): 18-24
8.Zhang Y#, Ren H#, Wang L#, Ning Z, Zhuang Y, Gan J, Chen S, Zhou D, Zhu H, Tan D, Zhang H*: Clinical impact of tumor-infiltrating inflammatory cells in primary small cell esophageal carcinoma. Int J Mol Sci 2014 May 30;15(6)
9.Zhu J#, Wang L#, Liu F, Pan J, Yao Z, Lin Y, Yang Y, Xiong X, Li K, Yang Y, Zhang Y, Chu X, Pan Y*, Zhang H*: Targeting PELP1 Attenuates Angiogenesis and Enhances Chemotherapy Efficiency in Colorectal Cancer. Cancers (Basel) 2022 Jan 13;14(2)
廣東省科學技術獎科技進步獎，二等獎，名稱：食管癌腫瘤标志物及液體活檢的應用與開發，排名第二
